Publication: Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides
2020 | AMERICAN SOCIETY OF CELL & GENE THERAPY
The identification of molecules that can modulate RNA or protein function and the subsequent chemical and structural optimization to refine such molecules into drugs is a key activity in drug discovery.
Publication: Enantiodivergent Formation of C–P Bonds: Synthesis of P-Chiral Phosphines and Methyl-phosphonate Oligonucleotides
JANUARY 17, 2020 | CHEMRXIV
A simple limonene-derived P(V)-based reagent for the modular, scalable, and stereospecific synthesis of chiral phosphines and methyl-phosphonate oligonucleotide (MPO) building blocks is presented.