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society-of-GTHPublication: Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides

2020 | AMERICAN SOCIETY OF CELL & GENE THERAPY

The identification of molecules that can modulate RNA or protein function and the subsequent chemical and structural optimization to refine such molecules into drugs is a key activity in drug discovery.


ChemRxivPublication: Enantiodivergent Formation of C–P Bonds: Synthesis of P-Chiral Phosphines and Methyl-phosphonate Oligonucleotides

JANUARY 17, 2020 | CHEMRXIV

A simple limonene-derived P(V)-based reagent for the modular, scalable, and stereospecific synthesis of chiral phosphines and methyl-phosphonate oligonucleotide (MPO) building blocks is presented.


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