SC1: Circular RNAs as a New Therapeutic Modality

MONDAY, MARCH 16 | 3:00 – 6:00 PM

ABOUT THIS COURSE:

Circular RNA (circRNA) is a type of single-stranded RNA which forms a continuous loop due to the covalent binding of its 3′ and 5′ ends. They are naturally formed in the cell and found to play a role in cancer, CNS, cardiovascular and other diseases. The closed loop structure makes it less susceptible to exonuclease-mediated degradation and presumably more stable than most linear RNAs, which is appealing from a therapeutic standpoint. Studies involving the formation and function of circRNAs are still preliminary, however, there is a lot of interest in exploring its role in disease and how they can they used. This course aims to provide an introduction to circRNA biology, their function and how they can be used in drug development. The chemistry leading to design and manufacturing of circRNAs as potential therapeutics, and issues dealing with dosing, biodistribution, immunogenicity will also be discussed.

INSTRUCTORS:

Samie Jaffrey, MD, PhD, Department of Pharmacology, Weill Medical College, Cornell University

Bojan Losic, PhD, Associate Professor, Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai

Additional instructors to be announced

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