Cambridge Healthtech Institute’s 5th Annual

mRNA & Emerging Nucleic Acid Modalities

Next-Generation Chemistries and Design Strategies for Increasing Efficacy and Targeted Delivery

March 18-19, 2027

Cambridge Healthtech Institute’s conference on mRNA & Emerging Nucleic Acid Modalities highlights the innovative chemistries, new biology, precise engineering/editing, and AI-driven design and optimization strategies to modify naturally occurring mRNA, tRNA, and DNA to overcome some of the limitations in existing nucleic acid-based therapies. The talks and discussions highlight how new nucleic acid modalities are being developed to improve efficacy, stability, dosing, frequency of administration, and toxicity making it one of the most promising areas in drug development.

Coverage will include, but is not limited to:

• Novel modifications and chemistries for improving efficacy and stability
• Use of mRNA, tRNA, circular RNA, saRNA, modified DNA, and RNA editing for tissue-specific impact
• In vivo CAR therapies for treating immune, CNS, skeletal, kidney, lung, and other disorders
• New engineering and AI/machine-learning tools for increasing oligo potency and safety
• Pursuing various pathways (degradation, activation, splicing, editing) to go after challenging drug targets
• Exploring oligo therapies for oncology, immunology, metabolism, CNS, inflammation, and beyond
• Building an IND-ready nonclinical package for novel oligonucleotide modalities
• Safety considerations for mRNA, oligo conjugates, and emerging modalities

The deadline for priority consideration is September 4th 2026.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

• To submit a podium presentation, please click here.

   

• To become a sponsor, click here.

   

• To present a poster, click here.

   

• To sign up to attend, click here.

For more details on the conference, please contact:

Tanuja Koppal, PhD

Senior Conference Director

Cambridge Healthtech Institute

Email: [email protected]

For sponsorship information, please contact:

Kristin Skahan

Business Development Manager

Cambridge Healthtech Institute

Phone: 781-972-5431

Email: [email protected]